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Shire Global

Investor Relations

ADR Holders Guide

Registered ADR holders may receive Shire plc’s shareholder documents (such as proxy material, disclosure documents, etc.) via the internet. As a registered ADR holder, i.e. if you do not hold your ADSs through a bank, broker or nominee account, you may receive your shareholder documents electronically by registering at the website http://www.computershare.com/investor and clicking on “EDelivery signup” on the right hand side of the screen. On the following screen, click on the drop-down arrow and locate Shire plc and follow the instructions.

If you do hold your shares via a bank, broker or nominee account, please contact your broker/agent to sign up to receive Shire plc shareholder documents electronically.

By following this link you will be leaving a Shire controlled website for a third party website. Please note that Shire is not responsible or liable for any third party website and the website may not be appropriate for all audiences.

By following this link you will be leaving the global Shire.com website for another Shire website. Please note that this website may not be appropriate for all audiences.

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